New blood test finds early risk for ovarian cancer

A molecular signal in the blood helps identify microscopic changes that precede the development of ovarian cancer, researchers have found, in a potential diagnostic breakthrough for a disease often discovered after it has already spread. For decades, efforts to detect ovarian cancer earlier have focused on finding smaller tumours, the researchers noted in their report published on Tuesday in Nature Medicine.

“We asked a fundamentally different question: What if we could identify the earliest molecular warning signs before invasive cancer even develops?” study leader Rajan Gogna of the Hoag Family Cancer Institute in Newport Beach, California, said in a statement. Ovarian cancer often begins with microscopic changes in the lining of the fallopian tubes.

The precancerous lesions are known as serous tubal intraepithelial carcinoma (STIC). The new study found that women with this precursor condition have elevated blood levels of an RNA molecule called Tu-Stroma.